leukocyte adhesion cascade

The leukocyte adhesion cascade is part of the inflammatory response, in which antigen-stimulated leukocytes extravasate in a series of steps:

1. capture (or transitory adhesion)
2. rolling
3. slow rolling
4. firm adhesion
5. transmigration across the endothelium (diapedesis)


Cytokines bind to proteoglycans:
● on the endothelial cell surface
● within the extracellular matrix

Particular chemokines ligate only with leukocytes that bear appropriate receptors, while leukocytes migrate along chemokine gradients. The selectin family of cellular adhesion molecules mediate function/migration of circulatory cells: L-leukocytes; E-endothelial cells; P-platelets and endothelial cells.

Џ animation of leukocyte adhesion, and explanation of animation Џ

Tables  Cell Adhesion Molecules  Cell signaling  Complement Receptors  Cytokines  Fc receptors  Immunoglobulins  Interferons Receptor Tyrosine Kinases (RTKs)  Receptor Signal Transduction  Scavenger Receptors  Second Messengers  Toll-like Receptors

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migration

Blood-borne cells of the immune system circulate through the body. Cellular migration in which cells through the capillary walls into the tissue is called diapedesis or extravasation.

Џ animation of leukocyte adhesion Џ

סּ adhesion סּ cell membranes סּ cell motility סּ cellular signal transduction סּ chemotaxis סּ cytoskeleton ~ immunoglobulins ~ integrins סּ microtubules סּ migration סּ phagocytosis סּ receptor proteins סּ receptor-mediated endocytosis • second messengers ~ selectins סּ signaling gradients ~ signaling items ¤ signaling molecules סּ signal transduction סּ two-component systems סּ transport סּ vesicle סּ

Tables  Fc receptors  Immune Cytokines  Immunoglobulins

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