leukocyte adhesion cascade
The leukocyte adhesion cascade is part of the inflammatory response, in which antigen-stimulated leukocytes extravasate in a series of steps:
1. capture (or transitory adhesion)
2. rolling
3. slow rolling
4. firm adhesion
5. transmigration across the endothelium (diapedesis)
Cytokines bind to proteoglycans:
● on the endothelial cell surface
● within the extracellular matrix
Particular chemokines ligate only with leukocytes that bear appropriate receptors, while leukocytes migrate along chemokine gradients. The selectin family of cellular adhesion molecules mediate function/migration of circulatory cells: L-leukocytes; E-endothelial cells; P-platelets and endothelial cells.
Џ animation of leukocyte adhesion, and explanation of animation Џ
Tables Cell Adhesion Molecules Cell signaling Complement Receptors Cytokines Fc receptors Immunoglobulins Interferons Receptor Tyrosine Kinases (RTKs) Receptor Signal Transduction Scavenger Receptors Second Messengers Toll-like Receptors
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1. capture (or transitory adhesion)2. rolling
3. slow rolling
4. firm adhesion
5. transmigration across the endothelium (diapedesis)
Cytokines bind to proteoglycans:
● on the endothelial cell surface
● within the extracellular matrix
Particular chemokines ligate only with leukocytes that bear appropriate receptors, while leukocytes migrate along chemokine gradients. The selectin family of cellular adhesion molecules mediate function/migration of circulatory cells: L-leukocytes; E-endothelial cells; P-platelets and endothelial cells.
Џ animation of leukocyte adhesion, and explanation of animation Џ
Tables Cell Adhesion Molecules Cell signaling Complement Receptors Cytokines Fc receptors Immunoglobulins Interferons Receptor Tyrosine Kinases (RTKs) Receptor Signal Transduction Scavenger Receptors Second Messengers Toll-like Receptors
▲ Top ▲
Labels: chemokines, extracellular matrix, extravasation, immunoglobulin receptors, inflammation, leukocyte adhesion cascade, proteoglycans, selectin